Amoxicillin trihydrate (a-amino-hydroxybenzyl-penicillin) is a semi synthetic, orally absorbed, broad-spectrum antibiotic. It is a drug of choice in the treatment of infections including chest (bronchitis/pneumonia), ears (otitis media), gonorrhea and urinary tract infections. The present work was carried out to formulate, optimize and evaluate a reconstitutable suspension of amoxicillin trihydrate for oral administration by using various techniques like physical mixing, solvent evaporation, co-grinding and lyophilization method with different suspending agents like xanthan gum, sodium alginate and compound tragacanth powder. The reconstitutable suspensions were evaluated for flow properties, particle size, pH, viscosity, sedimentation volume, redispersibility and drug release by in-vitro dissolution studies. The drug excipients Interactions and crystal morphology of optimized reconstitutable suspension were evaluated by FTIR and DSC analysis. The results indicated that the release of the amoxicillin trihydrate was rapid from all formulations than the pure drug. The drug release from the suspensions followed first order kinetics. Among all formulations the formulation prepared by lyophilization method released the drug rapidly than the pure drug and other formulations.
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